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Nuchal Translucency
Snijders RJ, Nobel P, Sebire N, Souka
A, Nicolaides KH. (1998)
UK multicentre project on the assessment
of risk of trisomy 21 by maternal age
and fetal nuchal translucency thickness
at 10-14 weeks of gestation.
Lancet.352(9125):343-6, Abstract
Multicentre study of 96127 women, investigated
for their risk of Trisomy 21 by a combination
of maternal age and nuchal translucency
thickness at 10-14 weeks gestation. Risk
was calculated by maternal age, gestational-age-related
prevalence and multiplied by a likelihood
ratio derived from the deviation from normal
of the Nuchal translucency measurement.
The sensitivity of a cut off risk of 1
in 300 was investigated. Phenotype was
derived from fetal karyotype or clinical
examination of liveborn infants. The estimated
Trisomy 21 risk was > 1in 300 for 8.3%
of normal pregnancies, 82.2% of those with
Trisomy 21 and 77.9% of those with other
chromosomal defects. 80% of affected pregnancies
were identified using the above screening
method to determine -those offered invasive
testing.
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